Genetic Cluster Computer

GCC citations

GCC serves as a computational and data hosting resource in many different scientific studies.
Currently GCC is the central computing resource in two large GWAS consortia: the Psychiatric GWAS Consortium, and the Tobacco and Genetics Consortium (TAG).

Below is a selection of published reports in which GCC was gratefully used and acknowledged:

2009

  • Boks MP, Derks EM, Weisenberger DJ, Strengman E, Janson E, Sommer IE, Kahn RS, Ophoff RA. The relationship of DNA methylation with age, gender and genotype in twins and healthy controls. PLoS One. 2009 Aug 26;4(8):e6767.
  • De Moor MH, Liu YJ, Boomsma DI, Li J, Hamilton JJ, Hottenga JJ, Levy S, Liu XG, Pei YF, Posthuma D, Recker RR, Sullivan PF, Wang L, Willemsen G, Yan H, DE Geus EJ, Deng HW. Genome-Wide Association Study of Exercise Behavior in Dutch and American Adults. Med Sci Sports Exerc. 2009 Sep 2. [Epub ahead of print]
  • Heap GA, Trynka G, Jansen RC, Bruinenberg M, Swertz MA, Dinesen LC, Hunt KA, Wijmenga C, Vanheel DA, Franke L. Complex nature of SNP genotype effects on gene expression in primary human leucocytes. BMC Med Genomics. 2009 Jan 7;2:1.
  • Medland SE, Duffy DL, Wright MJ, Geffen GM, Hay DA, Levy F, van-Beijsterveldt CE, Willemsen G, Townsend GC, White V, Hewitt AW, Mackey DA, Bailey JM, Slutske WS, Nyholt DR, Treloar SA, Martin NG, Boomsma DI. Genetic influences on handedness: data from 25,732 Australian and Dutch twin families. Neuropsychologia. 2009 Jan;47(2):330-7
  • Medland SE, Neale MC, Eaves LJ, Neale BM. A note on the parameterization of Purcell’s G x E model for ordinal and binary data. Behav Genet. 2009 Mar;39(2):220-9
  • Medland SE, Neale MC. An integrated phenomic approach to multivariate allelic association. Eur J Hum Genet. 2009 Aug 26. [Epub ahead of print]
  • Middeldorp CM, Sullivan PF, Wray NR, Hottenga JJ, de Geus EJ, van den Berg M, Montgomery GW, Coventry WL, Statham DJ, Andrews G, Slagboom PE, Boomsma DI, Martin NG. Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. Am J Med Genet B Neuropsychiatr Genet. 2009 Apr 5;150B(3):352-8.
  • Middeldorp CM, Vink JM, Hettema JM, de Geus EJ, Kendler KS, Willemsen G, Neale MC, Boomsma DI, Chen X. An association between Epac-1 gene variants and anxiety and depression in two independent samples. Am J Med Genet B Neuropsychiatr Genet. 2009 May 27. [Epub ahead of print]
  • Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J, et al. 2009 Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies. PLoS ONE 4(7): e6138. doi:10.1371/journal.pone.0006138
  • Pardo L, Bochdanovits Z, de Geus E, Hottenga JJ, Sullivan P, Posthuma D, Penninx BW, Boomsma D, Heutink P. Global similarity with local differences in linkage disequilibrium between the Dutch and HapMap-CEU populations. Eur J Hum Genet. 2009 Jun;17(6):802-10.
  • Posthuma D, de Koning DJ, Dolan C, Goddard ME, Visscher PM. A note on permutation tests for genetic association analysis of quantitative traits when variances are heterogeneous. Genet Epidemiol. 2009 Apr 13 [Epub ahead of print]
  • Sullivan PF, de Geus EJ, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Farmer A, Fava M, Gordon SD, He Q, Heath AC, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Hu Y, Kohli M, Lin D, Lucae S, Macintyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery GW, Muir WJ, Nolen WA, Nöthen MM, Perlis RH, Pirlo K, Posthuma D, Rietschel M, Rizzu P, Schosser A, Smit AB, Smoller JW, Tzeng JY, van Dyck R, Verhage M, Zitman FG, Martin NG, Wray NR, Boomsma DI, Penninx BW. Genome-wide association for major depressive disorder: a possible role for the presynaptic protein piccolo. Mol Psychiatry. 2009 Apr;14(4):359-75.
  • The Psychiatric GWAS Consortium. A framework for interpreting genomewide association studies of psychiatric disorders. Mol Psychiat, 2009 Jan;14(1):10-7
  • van den Berg SM. Imposing nonlinear constraints when estimating genetic and cultural transmission under assortative mating: a simulation study using Mx and BUGS. Behav Genet. 2009 Jan;39(1):123-31.
  • Vink JM, Smit AB, de Geus EJ, Sullivan P, Willemsen G, Hottenga JJ, Smit JH, Hoogendijk WJ, Zitman FG, Peltonen L, Kaprio J, Pedersen NL, Magnusson PK, Spector TD, Kyvik KO, Morley KI, Heath AC, Martin NG, Westendorp RG, Slagboom PE, Tiemeier H, Hofman A, Uitterlinden AG, Aulchenko YS, Amin N, van Duijn C, Penninx BW, Boomsma DI. Genome-wide association study of smoking initiation and current smoking. Am J Hum Genet. 2009 Mar;84(3):367-79.

2008

  • Battaglia M, Pesenti-Gritti P, Spatola CA, Ogliari A, Tambs K. A twin study of the common vulnerability between heightened sensitivity to hypercapnia and panic disorder. Am J Med Genet B Neuropsychiatr Genet. 2008 Jul 5;147B(5):586-93.
  • Franke L, de Kovel CG, Aulchenko YS, Trynka G, Zhernakova A, Hunt KA, Blauw HM, van den Berg LH, Ophoff R, Deloukas P, van Heel DA, Wijmenga C. Detection, imputation, and association analysis of small deletions and null alleles on oligonucleotide arrays. Am J Hum Genet. 2008 Jun;82(6):1316-33.
  • Hoekstra RA, Bartels M, Hudziak JJ, Van Beijsterveldt TC, Boomsma DI. Genetic and environmental influences on the stability of withdrawn behavior in children: A longitudinal, multi-informant twin study. Behav Genet. 2008 Sep;38(5):447-61.
  • Medland SE, Loehlin JC. Multivariate genetic analyses of the 2D:4D ratio: examining the effects of hand and measurement technique in data from 757 twin families. Twin Res Hum Genet. 2008 Jun;11(3):335-41.
  • Middeldorp CM, Hottenga JJ, Slagboom PE, Sullivan PF, de Geus EJ, Posthuma D, Willemsen G, Boomsma DI. Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype.Mol Psychiatry. 2008 Jan;13(1):84-9
  • Middeldorp CM, Hottenga JJ, Slagboom PE, Sullivan PF, de Geus EJ, Posthuma D, Willemsen G, Boomsma DI. Linkage on chromosome 14 in a genome-wide linkage study of a broad anxiety phenotype. Mol Psychiatry. 2008 Jan;13(1):84-9.

2007

  • De Moor MH, Spector TD, Cherkas LF, Falchi M, Hottenga JJ, Boomsma DI, De Geus EJ. Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs. Twin Res Hum Genet. 2007 Dec;10(6):812-20.